abstract：:Clinical two-dimensional (2D) Doppler ultrasound flow velocity measurement is important for determination of arterial wall shear stress, blood-tissue exchange, myocardial and valvular function. Such 2D Doppler flow velocity images are usually displayed in color, superimposed on the gray-scale, cross-section structural...

journal_title：Advances in experimental medicine and biology

authors： Adam DR,Kempner KM,Vivino MA,Tucker EE,Jones M

更新日期：1993-01-01 00:00:00

abstract：:The two major modalities of pharmacomechanical coupling, inositol 1,4,5, trisphosphate induced Ca2+ release and modulation of Ca(2+)-sensitivity, are reviewed. Recent studies show that although changes in cytoplasmic Ca2+ play the major role in regulating smooth muscle contraction, agonists can also significantly affe...

journal_title：Advances in experimental medicine and biology

authors： Somlyo AV,Somlyo AP

更新日期：1993-01-01 00:00:00

abstract：:An integrated left ventricular (LV) model is used to solve, simultaneously and interactively, the LV mechanics, the coronary blood flow and capillary and interstitial fluid and mass transport, and to analyze the LV behavior under normal as well as pathological conditions. Accounting for the interstitial fluid mass bal...

journal_title：Advances in experimental medicine and biology

authors： Zinemanas D,Beyar R,Sideman S

更新日期：1993-01-01 00:00:00

abstract：:The intramural blood vessels and fluid-filled interstitial space form a hydraulic continuum enmeshed by myocardial muscle layers and collagen matrix. Coronary circulation was found to be strongly influenced by passive and active properties of the muscle surrounding the coronary microvasculature. Selective remodeling o...

journal_title：Advances in experimental medicine and biology

authors： Kresh JY

更新日期：1993-01-01 00:00:00

abstract：:Oxygen deprivation following cessation of blood flow to vital organs such as brain, heart, and kidney is a ubiquitous human disease, invariably leading to devastating consequences. Studies in experimental models support the contention that membrane permeability is altered, ion fluxes impaired, and energy stores deplet...

journal_title：Advances in experimental medicine and biology

authors： Yavin E,Kunievsky B,Bazan NG,Harel S

更新日期：1992-01-01 00:00:00

abstract：:Neural tissue has generally been viewed as resistant to structural changes induced by exogenous factors. Research has shown that the brain responds to changes in diet by altering neurotransmitter synthesis, and by shifting neuroendocrine controls over a variety of physiological events. Animal model research also indic...

journal_title：Advances in experimental medicine and biology

authors： Clandinin MT,Suh M,Hargreaves K

更新日期：1992-01-01 00:00:00

abstract：:In using a reversed hypoosmotic lysis and resealing process, internalization of Naloxone or Naltrexone prodrugs as new opioid antagonists into red blood cells (RBC) can be obtained. We describe the entrapment method and haematological parameters of such RBC carriers. Percentages of internalization range between 35% an...

journal_title：Advances in experimental medicine and biology

authors： Noël-Hocquet S,Jabbouri S,Lazar S,Maunier JC,Guillaumet G,Ropars C

更新日期：1992-01-01 00:00:00

abstract：:The silicone tube model of regeneration has proved to be an invaluable tool for experimental studies aimed at understanding expression of growth factors during normal and abnormal metabolic states of regeneration. Since the morphological parameters of nerve growth and myelination are well-defined and easily identified...

journal_title：Advances in experimental medicine and biology

authors： Le Beau JM

更新日期：1992-01-01 00:00:00

abstract：:In this model of pancreatic regeneration, the initial trophic effect of cellophane wrapping is upon the ductular-epithelium, as shown by autoradiographic analysis following a single pulse of 3H-TdR. The uptake of 3H-TdR by ductular cells is maximal approximately 4 weeks before the peak uptake of the label by islet cel...

journal_title：Advances in experimental medicine and biology

authors： Rafaeloff R,Rosenberg L,Vinik AI

更新日期：1992-01-01 00:00:00

abstract：:This article reviews the factors influencing myocardial oxygen supply and demand. The regulative mechanisms in coronary blood flow, especially in critical conditions, are explained. Myocardial oxygenation in coronary artery disease is discussed with special reference to pharmacological intervention. An extensive evalu...

journal_title：Advances in experimental medicine and biology

authors： Fennema M,Erdmann W,Faithfull NS

更新日期：1992-01-01 00:00:00

abstract：:Exposure to hyperoxia, especially under hyperbaric conditions, causes an enhanced oxidative stress particularly in lung tissue. To test the potential hazardous effect of either a single or repeated hyperbaric oxygen treatment (HBO) on the cellular defence system the glutathione status of lung tissue from rats exposed ...

journal_title：Advances in experimental medicine and biology

authors： Purucker E,Lutz J

更新日期：1992-01-01 00:00:00

abstract：:The data of the O2 exchange through the surface of the skin show that a part of the normal upper skin can be supplied with O2 from the surrounding atmosphere. This may be important in pathological situations although probably simultaneous disturbances of the substrate supply may be more serious. The noninvasive contin...

journal_title：Advances in experimental medicine and biology

authors： Lübbers DW

更新日期：1992-01-01 00:00:00

abstract：:This review of the effects of hemidecortication in humans has been limited to studies of cognitive outcome published during the last 20 years. More directly than in the case of split-brain patients, the patients reviewed here attest to the remarkable ability of a single hemisphere, whether left or right, to support at...

journal_title：Advances in experimental medicine and biology

authors： Vargha-Khadem F,Polkey CE

更新日期：1992-01-01 00:00:00

abstract：:We infused endotoxin into anesthetized dogs while maintaining cardiac output. Whole body O2 uptake and arterial lactate concentration were measured at the same time with regional O2 uptake and lactate fluxes in muscle and gut. Even though whole body O2 uptake increased, so did arterial lactate levels. The different be...

journal_title：Advances in experimental medicine and biology

authors： Cain SM,Curtis SE

更新日期：1992-01-01 00:00:00

abstract：:To assess a significant role of hypoxic pulmonary vasoconstriction, HPV, on maintaining the gas exchange efficiency in acute lung injury, 24 mongrel dogs were treated with intravenously injecting 0.07 ml/kg of oleic acid. Hemodynamic and gas-exchange parameters were investigated at varied inspired O2 concentration, FI...

journal_title：Advances in experimental medicine and biology

authors： Yamaguchi K,Mori M,Kawai A,Asano K,Takasugi T,Umeda A,Yokoyama T

更新日期：1992-01-01 00:00:00

abstract：:These studies show that at least some--though certainly not all--of the adjuvant effects of LPS and its derivatives can be attributed to its ability to eliminate the inhibitory effects of Ts which are activated during the course of a normal immune response. The ability of nontoxic MPL to act in this fashion suggests t...

journal_title：Advances in experimental medicine and biology

authors： Baker PJ,Taylor CE,Ekwunife FS

更新日期：1992-01-01 00:00:00

abstract：:Nuclear magnetic resonance (NMR) techniques are being increasingly utilised as an in vivo method to monitor tissue oxygen concentration in various organs. In muscle and heart, proton NMR spectroscopy of myoglobin has been used to calculate local oxygen tension through the oxygen sensitivity of the histidine group sign...

journal_title：Advances in experimental medicine and biology

authors： Vink R

更新日期：1992-01-01 00:00:00

abstract：:This contribution on the biology and management of bone metastases from prostatic cancer is divided into three parts. The first details a study conducted at Stanford University on the prevention of bone metastases in the lumbar spine, in patients in whom the lumbar spine has been irradiated coincidental to the radiati...

journal_title：Advances in experimental medicine and biology

authors： Bagshaw MA,Kaplan ID,Valdagni R,Cox RS

更新日期：1992-01-01 00:00:00

abstract：:The present study shows for the first time, the response in active and passive forces of skeletal muscles to tourniquet ischemia. These responses were shown for both fast and slow twitch muscle types in the same rat hindlimb. Our data agrees partially with metabolic studies on ischemic skeletal muscles. The difference...

journal_title：Advances in experimental medicine and biology

authors： Carvalho AJ,McKee NH

更新日期：1992-01-01 00:00:00

abstract：:The results of these studies indicate that voluntary activity suppresses the development of chemically and virally induced primary mammary tumors in rats and mice fed high-fat diets. These diets were chosen to mimic the current U.S. fat consumption of approximately 40% of calories as fat. It remains to be seen if acti...

journal_title：Advances in experimental medicine and biology

authors： Cohen LA,Boylan E,Epstein M,Zang E

更新日期：1992-01-01 00:00:00

abstract：:The binding sites for dermatan sulfate and heparin in HCII overlap but are not identical. This may explain the observation that HCII binds non-specifically to heparin oligosaccharides but preferentially binds to a minor hexasaccharide isolated from dermatan sulfate having the structure shown in Fig. 4B. The tissue dis...

journal_title：Advances in experimental medicine and biology

authors： Tollefsen DM

更新日期：1992-01-01 00:00:00

abstract：:We developed a new 4-dimensional differentiation model of growth-cartilage cells (temporally and spatially regulated). composed of a high-density suspension culture of rabbit costal chondrocytes. In this system, fibroblast growth factor (FGF) or transforming growth factor-beta (TGF beta) stimulated proliferation and m...

journal_title：Advances in experimental medicine and biology

authors： Suzuki F

更新日期：1992-01-01 00:00:00

abstract：:Using the model of isolated myocytes, we have investigated under current- and/or voltage-clamp conditions: (i) the time-course of H2O2-induced changes in the action potentials and the contractility. (ii) the effect of pharmacological tools such as ryanodine, TTX and nifedipine on H2O2-induced changes; (iii) the effect...

journal_title：Advances in experimental medicine and biology

authors： Horackova M,Beresewicz A

更新日期：1992-01-01 00:00:00

abstract：:Direct studies linking drugs of abuse with changes in neurotransmitters and subsequent effects on the immune system are not abundant. One can, however, hypothesize that an indirect effect can occur since a variety of neurotransmitters known to be acted on by various drugs of abuse can, in turn, be correlated with chan...

journal_title：Advances in experimental medicine and biology

authors： Hall NR,O'Grady MP,Menzies RA

更新日期：1991-01-01 00:00:00

abstract：:Maturation of the fetal lung is a complex process involving interactions between intrinsic biologic development of several cell types and hormonal triggering of biochemical and functional alterations. Catecholamines, corticosteroids, thyroid hormones and perhaps prolactin, all influence the transition from non-functio...

journal_title：Advances in experimental medicine and biology

authors： O'Brien WF

更新日期：1991-01-01 00:00:00

abstract：:IFN-gamma is the most effective principle responsible for IDO induction in human cells in vitro. Lymphocyte factors support the effect of other IFN species. Induction of IDO and influence of various factors on IDO is correlated to pteridine synthesis. Cooperative effects of several mediators may account for in vivo ob...

journal_title：Advances in experimental medicine and biology

authors： Werner-Felmayer G,Werner ER,Fuchs D,Hausen A,Reibnegger G,Wachter H

更新日期：1991-01-01 00:00:00

abstract：:Using several novel in vitro culture systems, we have examined the tissue-specific regulation of the proglucagon-derived peptides, at the levels of proglucagon gene expression and pGdp synthesis and secretion. Our studies indicate that proglucagon gene expression in intenstine, hypothalamus and pancreas is under the r...

journal_title：Advances in experimental medicine and biology

authors： Brubaker PL,Stobie KM,Roberge JN,Lui EY,Drucker DJ

更新日期：1991-01-01 00:00:00

abstract：:This study investigated the increase in gastric acid secretion induced by intravenous administration of 2-deoxy-D-glucose (2-DG; 60 mg kg-1), insulin (5 U kg-1) or by electrical stimulation of the vagus nerve (1 mA, 1 ms, 3 Hz) in urethane-anesthetized rats pretreated when newborn with either capsaicin or the vehicle....

journal_title：Advances in experimental medicine and biology

authors： Evangelista S,Santicioli P,Maggi CA

更新日期：1991-01-01 00:00:00

abstract：:In summary, the studies reviewed here have indicated which neural functions might be directly influenced by the nucleus basalis. Basalis neurons do not appear to be directly involved in trial-specific memory because, in memory tasks, they have non-differential responses that do not correspond to the information being ...

journal_title：Advances in experimental medicine and biology

authors： Richardson RT,DeLong MR

更新日期：1991-01-01 00:00:00

abstract：:Insulin-like growth factor II (IGF-II) belongs to the insulin family of peptides and acts as a growth factor in many fetal tissues and tumors. The gene expression of IGF-II is initiated at three different promoters which gives rise to multiple transcripts. In a human rhabdomyosarcoma cell line IN 157 IGF-II mRNAs of 6...

journal_title：Advances in experimental medicine and biology

authors： Gammeltoft S,Christiansen J,Nielsen FC,Verland S

更新日期：1991-01-01 00:00:00

abstract：:The compressive mechanical properties of freeze-dried green beans show a pronounced decrease in rigidity when moisture content and/or temperature are increased. There exist several temperature and moisture combinations which give common values for mechanical properties. These combinations also give a common compressiv...

journal_title：Advances in experimental medicine and biology

authors： Emami C,Flink JM

更新日期：1991-01-01 00:00:00

abstract：:This paper reviews recent work on the interactions among solutes, polymers, and water in model food systems. Four possible combinations of ionic or non-ionic solutes and polymers are discussed in terms of their water sorption behavior. Comparisons between experimental values and values calculated by a mass balance equ...

journal_title：Advances in experimental medicine and biology

authors： Chinachoti P,Schmidt SJ

更新日期：1991-01-01 00:00:00

abstract：:Volume changes arising from the sorption of water by three starches have been determined by dilatometry. By a recently described method, parameters of the G.A.B. equation have been used to resolve the volume changes into contributions from strongly sorbed water molecules in contact with the surface and from weakly sor...

journal_title：Advances in experimental medicine and biology

authors： Strauss UP,Porcja RJ,Chen SY

更新日期：1991-01-01 00:00:00

abstract：:Thermomechanical Analysis (TMA), using the parallel-plate-rheometer mode of the DuPont 943 TMA, was used to evaluate the softening properties of frozen aqueous carbohydrate model systems. A sample (of fixed dimension) of frozen solution was placed between the parallel plates and cooled to -80 degrees C. The sample was...

journal_title：Advances in experimental medicine and biology

authors： Maurice TJ,Asher YJ,Thomson S

更新日期：1991-01-01 00:00:00

abstract：:The recruitment of monocytes from the peripheral vasculature to an area of chronic inflammation is a complex phenomenon. This complicated process is likely mediated to a large extent by chemotactic cytokines that are expressed via a cytokine cascade. A number of chronic diseases that are difficult to manage are charac...

journal_title：Advances in experimental medicine and biology

authors： Kunkel SL,Standiford T,Kasahara K,Strieter RM

更新日期：1991-01-01 00:00:00

abstract：:Pretreatment of rats with large doses of vitamin A (retinol) dramatically increased the hepatotoxicity of carbon tetrachloride (CCl4). Experiments were performed to elucidate the mechanism of this potentiation. Hypervitaminosis A was produced by oral administration of retinol, 250,000 IU/kg for seven days. CCl4 was th...

journal_title：Advances in experimental medicine and biology

authors： Sipes IG,el Sisi AE,Sim WW,Mobley SA,Earnest DL

更新日期：1991-01-01 00:00:00

abstract：:The results of these studies suggest that halothane, in addition to its effect of reducing the trans-sarcolemmal Ca2+ influx, has a direct effect on the function of the sarcoplasmic reticulum by making the organelle leaky to Ca2+ and reducing the amount of Ca2+ stored. Isoflurane, on the other hand, does not appear to...

journal_title：Advances in experimental medicine and biology

authors： Komai H,Rusy BF

更新日期：1991-01-01 00:00:00

abstract：:To assess whether the dipeptide N-epsilon-(gamma-L-glutamyl)-L-lysine (glutamyl-lysine) can serve as a nutritional source of lysine, we compared the growth of mice fed (a) an amino acid diet in which lysine was replaced by six dietary levels of glutamyl-lysine; (b) wheat gluten diets fortified with lysine; (c) a wheat...

journal_title：Advances in experimental medicine and biology

authors： Friedman M,Finot PA

更新日期：1991-01-01 00:00:00

abstract：:Poultry breeding has economical importance for the people living in Bursa and surrounding villages. Similar to some sporadic disease, gout can also be reason for production loses and death in laying and broiler chickens. Gout cases have been observed in some pens of a big poultry company. In this study 20 healthy cont...

journal_title：Advances in experimental medicine and biology

authors： Mert N

更新日期：1991-01-01 00:00:00

abstract：:The relationship between temperature and seasonal fluctuations in births is presented cross nationally. Previous literature which give some credence to this relationship is reviewed, but the authors caution that there is no singular reason for birth seasonality. The summary conclusion is that the evidence is inconcl...

journal_title：Advances in experimental medicine and biology

authors： Lam DA,Miron JA

更新日期：1991-01-01 00:00:00